6th International Meeting on Quadruplex Nucleic Acids, Prague, Czech Republic, May 31st - June 3rd, 2017

Scientific Program


Day 1 (Wednesday May 31):

Registration starts from 10:00

13:30 – 13:45 Opening remarks: Lukas Trantirek
13:45 – 14:05 Opening lecture: Jean-Louis Mergny - Quadruplexes are everywhere!
14:05 - 14:50 Meeting keynote lecture: Martin Gellert - G quartets: the pre-history and its consequences

SESSION 1 – Quadruplex structure

  Chair: Anh Tuan Phan
14:50 – 15:25 KL1: Janez Plavec -  Fascinating NMR structures of tetrahelical DNA different from G-quadruplexes
15:25 – 15:45 L1: Claudia Sissi - Conformational profiling of G-quadruplex units in cKIT promoter as tool to drive the rational design of new chemotherapeutics
15:45 – 16:05  L2: Vojc Kocman - AGCGA-quadruplexes a novel tetrahelical structural family
16:05 – 16:35 Coffee break
  Chair: Anh Tuan Phan
16:35 – 16:55  L3: Jiri Sponer - Structural dynamics and folding of DNA quadruplexes: Theory and experiment.
16:55 – 17:15 L4: Peter Unrau - Converting a G-quadruplex based fluorophore binding aptamer into an efficient bimolecular fluorescent switch
17:15 – 17:35 L5: Jonathan B. Chaires - How POT1 unfolds G4 DNA
17:35 – 17:55 L6: Mikayel Aznauryan - Folding dynamics of G-quadruplex DNA in physiologically relevant milieu: moving towards in vivo
17:55 – 18:15 L7: Vitaly Kuryavyi - An unprecedented DNA structure with parallel- and antiparallel-stranded segments bridged by conjoined base triples
18:15 – 19:00 Poster flash presentations I
19:00 – 21:30 Poster session I with  Welcome dinner

Day 2 (Thursday June 1)

SESSION 2 – G4 targets/ Quadruplex ligands

Chair: Janez Plavec
9:00 – 9:35 KL2: Anh Tuan Phan - G-quadruplex structure, dynamics and recognition implications for the development of G-quadruplex ligands
9:35 – 9:55 L8: Concetta Giancola - Stability of G-quadruplexes and their ligand interactions: a thermodynamic insight.
9:55 – 10:15 L9: Ramon Vilar - Studying Ligand-Quadruplex DNA Interactions in Live Cells by Fluorescence Lifetime Imaging Microscopy
10:15 – 10:35  L10: Daniela Montesarchio - Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes
10:35 - 11:05 Coffee break
Chair: Janez Plavec
11:05 – 11:40 KL3: Naoki Sugimoto - New targets of pharmaceutical drugs; Non-canonical DNA and RNA.
11:40 – 12:00  L11: Balci Hamza - A Single Molecule Approach to Study G-quadruplex, Protein, and Small Molecule Interactions
12:00 – 12:20  L12: Antonio Randazzo - DNA G-quadruplex interacting proteins: from identification to characterization
12:20 – 12:40 L13: Valerie Gabelica - A mass spectrometry insight into G-quadruplex folding and ligand binding
12:40 - 14:00 Lunch


Chair: Antonio Randazzo
14:00 – 14:35 KL4: Stephen Neidle - Where we are with the development of G4 drugs in human cancer
14:35 – 14:55 L14: Marie-Paule Teulade-Fichou - Visualization strategies and molecular tools for probing the G4 genome.
14:55 – 15:15 L15: John Trent - Targeting the human telomere quadruplex system
15:15 – 15:35 L16: Carika Weldon -Specific G-quadruplex ligands regulate the alternative splicing of Bcl-X
15:35 16:05 Coffee break

SESSION 3A – Quadruplex nanotech and biotech

Chair: Antonio Randazzo
16:05 – 16:40 KL5: Dipankar Sen - A new molecular tool to fish for G-quadruplexes in cells?
16:40 – 17:00 L17: Hiroshi Sugiyama - Chemical Biology of G-quadruplex
17:00 – 17:20  L18: Paula J.Bates - Antiproliferative G-Quadruplex Oligos: How do they REALLY work?
17:20 – 17:40 L19: Scarlett Dvorkin - High Throughput Tools for Whole Genome Quadruplex Characterization
17:40 – 18:25  Poster Flash Presentations II
18:25 21:30  Poster session II Wine and Cheese party

Day 3 (Friday June 2)

SESSION 3 A– Quadruplex nanotech and biotech / unusual DNA structures

Chair: Jean-Louis Mergny
9:00 – 9:35 KL6: Itamar Willner - Quadruplex Nucleic Acids for Molecular Devices and Functional Materials
9:35 – 9:55  L20: Omer Lustgarten - Asymmetric G-Quadruplex DNA Scaffolds and their Application as Combinatorial Sensors and Molecular Security Systems
9:55 – 10:15 L21: Miroslav Fojta - Exploring DNA structure by electrochemical methods
10:15 – 10:35 L22: Andrea Tanzer - Prediction of RNA G4 Structures in The Light of Their Sequence Context
10:35 – 11:05 Coffee break

SESSION 3B – The i-motif corner

Chair: Jean-Louis Mergny
11:05 – 11.025 L23: Zoe Waller - Adventures with the “other” strand: stabilising i-motif structures and effects of epigenetic modification
11.25 – 11.45 L24: Carlos González - I-motifs at neutral pH
11.45 – 12.10 Poster Flash Presentations III
12:10 – 13:40 Lunch


SESSION 4 – G4 biology

Chair: Nancy Maizels
13:40 – 14:15 KL7: Sir Shankar Balasubramanian - Existence and consequences of G-quadruplex structures in DNA.
14:15 – 14:35: L25:Cynthia J. Burrows - Gene Induction Activity of G4s in Promoters
14:35 – 14:55: L26: Nora Calcaterra - G-quadruplexes: non-canonical DNA structures controlling life from the beginning            
14:55 – 15:15  L27: Tracy BryanImplications of G-quadruplexes for human telomere maintenance mechanisms
15:15 – 15:35  L28: Guillaume Guilbaud - G-quadruplex replication and epigenome maintenance
15:35 – 16:05 Coffee break
Chair: Nancy Maizels
16:05 – 16.25: L29: Alain Nicolas - Role of G quadruplexes in genome instability
16.25 – 16.45: L30: Giovanni CapranicoModulation of R loops and DNA damage by G4 binders
16:45 – 17:05: L31: Jens Kurreck - Proteomic Analysis of the Biological Function of RNA Guanine-Quadruplex Motifs in the 5’-UTR of mRNAs
17:05 – 17:25 L32: Vivekanandan Perumal - A G-quadruplex motif in the HBV genome enhances transcription and virion secretion
17:25 – 17:45 L33: Marie-Line AndreolaG-quadruplex nucleic acids in HIV-1: function and therapeutic applications
17:45 – 18:05  L34: Ilaria Frasson - G-quadruplex presence, conservation and location in all human viruses; a close-up on retroviruses and herpes viruses
18:05 – 18:50 Poster session III.
20:00 – 22:30 Gala dinner

Day 4 (Saturday June 3)

SESSION 4 – G4 biology

Chair: Paula Bates
9:00 – 9:35 KL8: Nancy Maizels - G-quadruplexes in human health and disease
9:35 – 9:55 L35: Robin van Schendel - Dealing with G-quadruplexes that hamper ongoing DNA replication
9:55 – 10:15 L36: Marta Fay - G-quadruplexes under stress
10:15 – 10:35 L37: Danzhou Yang - Promoter G-quadruplexes: structure, function and diversity
10:35 11:05 Coffee break
Chair: Paula Bates
11:05 – 11:25 L38: Pavel Ivanov - Diverse biology of RNA G-quadruplexes
11:25 – 11:45 L39: Samuel Rouleau RNA G-Quadruplexes regulate the biogenesis and function of cancer related microRNAs
11:45 – 12:30  Closing – Awards ceremony
12:30 13:30 Lunch



Poster presentation

Please note that size of the poster board is A0, portrait oriented.

The posters will be displayed from Wednesday, 31st of May till Saturday 3rd of June. It is possible to hang the posters in the Poster session hall at the first floor of the hotel (please follow the signs) from 12:00 am, Wednesday May 31st. Posters should be removed before 9:00 am, Saturday June 3rd.

Poster session is scheduled as follows:

Poster session I: Wednesday, 31st May from 19:00 till 21:30, posters no. 1- 95,

Poster session II: Thursday, 1st June from 18:25 till 21:30, posters no. 96 - 191

Poster session III: Friday 2nd June from 18:05 till 18:50.

Only posters submitted to poster competition (P: 001, 002, 006, 008 009, 010, 011, 014, 019, 020, 021, 027, 028, 030, 038, 055, 057, 061, 063, 065, 071, 072, 076, 077, 082, 087, 089, 094, 095, 098, 104, 110, 116, 119, 124, 130, 132, 148, 151, 163, 166, 179, 180, 189)

Poster Flash Presentation

Only posters submited for students poster competition will be presented during Poster Flash Presentation.

List of posters

Org. No.SurnameNameTopicTitle
P001AbdelhamidMahmoudUnusual (non G4) nucleic acidsCu+ stabilizes and induces cytosine-cytosine base pairs in i-motif DNA
P002Abou AssiHalaStructureTrapping G-quadruplex/i-Motif Intermediates of Human Telomeric DNA
P003AmatoJussaraStructureInsights into G-quadruplex recognition by HMGB1 protein
P004AndrałojćWitoldStructureUnraveling the structural basis for the exceptional stability of RNA G-quadruplexes capped by the GGU sequence at the 3’ terminus
P005ArmasPabloBiologyChaperoning RNA and DNA G-quadruplexes that control proto-oncogenes expression.
P006BakalarBlazStructureA minimal left-handed G-quadruplex motif
P008BansalVarunBiologyG-quadruplex in the promoter of proto-oncogene Bcl3 is essential for controlling the expression of Bcl3
P009BartolucciLauraBiologyG-quadruplex Nucleic Acids in HIV-1
P010BaxterColetteBiologyThe regulation of growth by G-Quadruplex dependant processes in the plant model species Arabidopsis thaliana.
P011BekovaKaterinaUnusual (non G4) nucleic acidsThe G-hairpin formation propensity
P012BeniaminovArtemyLigandsUsing of Porphyrin Derivatives for Study of G-quadruplexes within Double-Stranded DNA
P013BirkedalVictoriaLigandsFolding and conformational heterogeneity of human telomeric G-quadruplexes following ligand binding
P014BiswasBanhiBiologyCo-evolution of G-quadruplexes in viruses and the infected hosts
P015BlondelMarcBiologyA yeast-based assay identifies a host cell protein required for the Epstein-Barr virus-encoded EBNA1 immune evasion through binding to G-quadruplexes of EBNA1 mRNA
P016BourdoncleAnneUnusual (non G4) nucleic acidsG-quadruplexes unfolding by proteins
P017BrazdaVaclavMethodologyA novel H/D exchange mass spectrometry approach to assess protein interactions with quadruplex DNA
P018BrazdovaMarieBiologyG-quadruplexes as regulatory motifs in p53 world
P019BrčićJasnaStructureTwo G-quadruplex structures formed by DNA oligonucleotide with GGGGCC repeats linked to ALS and FTD
P020CarducciFedericaNanotech-BiotechG4-based Hydrogels as a possible tool for protein crystallization
P021CarvalhoJosuéLigandsKRAS-22RT G-quadruplex stabilization by Acridine Orange derivatives
P022ChakrabortyGurudasNanotech-BiotechMetal-Free DNA Structure and Catalytic Activity in Organic Solvents by Noncovalent Functionalization
P023ChalikianTigranStructureIonic Effects on G-quadruplex Stability
P024ChatterjeeSubhrangsuBiologyArresting G-Quadruplex structure at LNC-X2 (Long Non Coding RNA–X2) promoter to inhibit Cancer Metastasis
P025ChatterjeeSubhrangsuBiologyImpediment of Quadruplex-mediated c-MYC transcription by Synthetic peptides via Stabilizing Pu27 quadruplex: a novel avenue in anti-cancer therapy
P026ChenShuo-BinLigandsA novel cell imaging assay for identifying NRAS RNA G-quadruplex ligands based on GTFH probe
P027ChenJielinMethodologyA Novel Method to Construct High-Activity G-quadruplex/hemin DNAzymes
P028ChilkaPallaviStructureSelective Recognition of G-Quadruplexes by Dimeric Carbocyanine Dyes
P029ChorellErikLigandsDesign and synthesis of molecular tools to study G4 structures
P030CravenHollyBiologyG-quadruplexes in the parasitic platyhelminth Schistosoma mansoni: identification and anthelmintic suitability
P031CristofariCamillaUnusual (non G4) nucleic acidsEGFR promoter region: structural characterization of the C-rich sequence
P032CroquetteVincentBiologyReal time unfolding of G-quadruplex by helicases and polymerases
P033CruzCarlaLigandsG-quadruplexes stabilization by phenanthroline-bis-oxazole ligands
P034DaoThuanMethodologyEnhancement of intrinsic fluorescence in G-quadruplexes: mechanism of excimer formation
P035DasRabindra NathLigandsDesign, Synthesis, and Evaluation of 2,9 Bis[(substitutedaminomethyl) phenyl]-1,10-phenanthroline Derivatives as G-Quadruplex Ligands
P036DasPoulomiLigandsInteraction of Telomestatin derivatives with human telomeric DNA: Trapping of DNA in a parallel-stranded G-quadruplex conformation
P037DavidAldana PaulaBiologyNovel transcriptional regulatory mechanism for a gene involved in craniofacial development: G-quadruplex modulation by a nucleic acid chaperone.
P038De MagisAlessioBiologyG-quadruplex binders cause DNA damage by inducing R loops in human cancer cells
P039DefrancqEricBiologyTopologically constrained G-quadruplexes: new tools for the identification of proteins partners
P040Del Villar-GuerraRafaelStructureAnalysis of Circular Dichroism Spectra of G-Quadruplexes
P041DembskaAnnaNanotech-BiotechSpectroscopic study of fluorescent probes based on G-quadruplex oligonucleotides labeled with ethynylpyrenyldeoxyuridine
P042DembskaAnnaUnusual (non G4) nucleic acidsHairpin integrated with i-motif domain containing a tricyclic cytosine analogue
P043DemkovicovaErikaLigandsAnalysis of Ebola virus derived G-quadruplexes and thiazole orange interactions
P044Di AntonioMarcoMethodologyDynamic live cell imaging of single DNA G-quadruplexes with Light-Sheet Microscopy
P045Di PrimoCarmeloStructureStructural basis of 93del dimerization with potassium and sodium cations
P046DickerhoffJonathanStructureThe Butterfly Effect: Modified Nucleotides for Analyzing DNA and RNA Quadruplex Folds
P047DoriaFilippoLigandsNaphthalene diimide Cu(II) Complex, a Selective Scissoring Tool for Quadruplex Nucleic Acids.
P048Drevenšek-OlenikIrenaNanotech-BiotechTunable Thin-Film Structures of Lipophilic Guanosine Derivatives
P049DvořákováZuzanaStructureInfluence of naturally occurring damage on formation and stability of human telomere i-motif
P050DžatkoŠimonStructureCharacterization of Non-B DNA structures in complex environment of mammalian cells by in cell NMR spectroscopy
P051FlemingAaronStructureZika viral genomic RNA possesses G-quadruplexes are characteristic of the Flaviviridae family
P052LagoSaraBiologyA new protocol for kinetic analysis of 1H6 monoclonal antibody and G-quadruplex nucleic acids using surface plasmon resonance biosensing
P053FuYanNanotech-BiotechG-quadruplex and i-motif: Promising Candidates in Biosensing
P054FunkeAndreaLigandsCalorimetric Studies for Dissecting the Energetics of Indolo[3,2-b]quinolines Binding to Parallel G-Quadruplexes
P055GarajskýMartinUnusual (non G4) nucleic acidsDNA G-hairpin
P056GalerPetraStructureG-quadruplex system in dynamic equilibrium triggered by (de)protonation reaction
P057GarantJean-MichelMethodologyG4RNA screener a motif independent identification of potential RNA G-quadruplexes
P058GargalloRaimundoMethodologyStudy of conformational equilibria of G-quadruplex and i-motif structures by means of multivariate analysis
P059GazanionElodieBiologyG-quadruplex-mediated regulation of malaria parasites virulence
P060GiassaIlektra-CharaStructureStructure of a G-quadruplex in the Green Monkey c-kit promoter
P061GötzSilviaBiologyZuo1 - a novel G4-binding protein
P062GranqvistLottaMethodologyMonitoring of G-Quadruplex/Hairpin Transitions by 19F NMR Spectroscopy
P063GriffinWezleyStructureRecognition of G4DNA by Positive coactivator 4: An expanded model of DNA recognition by a transcriptional coactivator
P065GruenTassiloStructureInvestigation of Promoter G-Quadruplex Folding Dynamics using Real-Time NMR-spectroscopy
P066GudanisDorotaStructureInfluence of chemical modification on RNA duplex-quadruplex hybrid formation.
P067Haensel-HertschRobertBiologyG-quadruplex structures mark human regulatory chromatin
P068HeMingzeBiologyG4 quadruplexes in and near regulatory elements of maize genes involved in tissue development and altered transcriptional response to abiotic stresses
P069HubertSandrineStructureAFM-based single molecule force spectroscopy on bimolecular hybrid DNA/RNA G-quadruplexes
P070HudecekOldrichUnusual (non G4) nucleic acidsDevelopment of capturing technique for 5’-diphosphate RNA
P071HurJeong HwanLigandsIdentification of a new Z-DNA inducer using SYBR Green 1 as a B-to-Z transition sensor
P072IaccarinoNunziaLigandsToward the development of specific G-quadruplex binders: biophysical studies of new hydrazone derivatives
P073IshizukaTakumiMethodologyA multi-functional guanine derivative for studying DNA G-quadruplex structure in vitro and in living cells
P074IslamBariraStructurePropeller Loop Conformations of Human Telomeric Quadruplex in MD Simulations Carried out in Molecular Crowding Conditions
P075JamroskovicJanLigandsEvaluation of new G4 binding analogues based on compounds identified in high throughput screening
P076JodoinRachelBiologyA 5’-UTR RNA G-Quadruplex structure affects both the cap-dependent and independent translation of BAG-1, an mRNA involved in colorectal cancer
P077JordanDeondreUnusual (non G4) nucleic acidsThe secondary structure of CAGAGG repeats linked to replication fork collapse
P078JurečkaPetrMethodologyNew Force Fields for Quadruplex Simulations - Performance, Comparison and Challenges
P079JuskowiakBernardNanotech-BiotechCation-sensitive fluorescent probes based on tetraplex DNA structures
P080Kalliat ThazhathveetilArunNanotech-BiotechHole transport through G-quadruplexes
P081KaluzhnyDmitryLigandsThe third side chain of anthraquinone derivatives leads to an increase in affinity and selectivity for telomeric G4
P082KargBeatriceStructureTetrad Polarity Reversal And Exchange Dynamics of Single Residues in Monomolecular Quadruplexes
P083KejnovskáIvaStructureClustered abasic lesions profoundly change the structure and stability of human telomeric G-quadruplexes
P084KejnovskyEduardBiologyEffect of G-quadruplexes on expression of plant transposable elements
P085KirillovaYuliyaStructureChiral anionic PNAs: triplex formation and binding to G4 targets
P086KosmanJoannaNanotech-BiotechModifications of peroxidase-mimicking DNAzymes
P087KotarAnitaLigandsNMR study of triangulenium optical probe binding to a G-quadruplex
P088KrafčíkDanielBiologyALT specific telomeric repeat variant remodels conformational properties of telomeric C-rich DNA
P089KrafčíkováMichaelaLigandsMonitoring DNA-ligand interactions using in cell NMR spectroscopy
P090KreuzmannDeniseBiologyARPC2 translation is mediated by a G-quadruplex-containing internal ribosome entry site and regulated by different 5´UTR splice variants
P091KumariRomikaBiologyPrediction of translational pauses caused by pharmacological stabilization of G-quadruplexes using ribosome profiling
P092LahJurijStructureWhy a single guanine-rich DNA sequence folds into different G-quadruplex structures?
P093LavergneThomasLigandsStudies of G-Quadruplexes/Ligands Interactions by Surface Plasmon Resonance and Bio-Layer Interferometry
P094LeeChun-YingBiologySystematic and quantitative analysis of G-quadruplex DNA folding and its effect on gene expression
P095LefebvreJoelLigandsVisualization of G-quadruplex ligands by click-chemistry in cells
P096LexaMatejMethodologyExtensive exploration of G4 combinatorial space in potential quadruplex searches with imperfection-tolerant R/Bioconductor package PQSfinder improves results on experimental datasets
P097LičenMatjažNanotech-BiotechPhotoregulating the self-assembly of lipophilic guanosine derivatives in thin surface films
P098LiuKimLigandsEvaluating bicyclic peptides as G-quadruplex ligands
P100MaYueLigandsSynthesis and evaluation of ligand for selective induction of topologies in telomeric G-quadruplex
P101MacgregorRobertStructureThe curiously small molar volume of formation of tetra-molecular GQ's
P102MaityArijitStructureStructure of an unprecedented quadruplex-duplex hybrid formed by the C9ORF72 hexanucleotide GGGGCC repeat
P103MandalSohamLigandsTuning Copper(II) mediated stabilization of pyridine modified tetramolecular G-quadruplexes
P104MannaSudeshnaStructureProbing Human Telomeric DNA Repeat in Cell Models Using Conformation-Sensitive Nucleoside Analogs
P105MareckiJohnBiologyImmunofluorescent detection of G4DNA in yeast and mammalian cells
P106MarshThomasNanotech-BiotechThe use of G-Wires as a Supramolecular G-DNA Scaffold.
P107Martin-PintadoNereaBiologyDeciphering the molecular mechanisms that resolve G-quadruplex structures during DNA replication
P108MarušičMajaStructureIn reverse: the effect of DNA sequence inversion on G-quadruplex folding
P109MerrickCatherine JillBiologyRecQ helicases and G4s affect virulence gene expression and genome stability in the human malaria parasite Plasmodium falciparum
P110MigliettaGiuliaBiologyTargeted gene therapy for pancreatic cancer: anthraquinone derivatives bind to G-quadruplex cluster in KRAS mRNA and suppress translation.
P111MiyoshiDaisukeLigandsA new photodynamic therapy targeting mRNA G4
P112MohammadJani BashaBiologyS. pombe Pfh1 unwinds stably formed G-quadruplex DNA structures derived from evolutionarily conserved G-quadruplex motif containing regions in the fission yeast genome
P113MojzešPeterStructureInterquadruplex transitions of human telomeric sequences in K+ solutions under molecular crowding conditions and sub-melting temperatures
P114MonchaudDavidLigandsEver smarter synthetic G-quartets
P115MoralesJuan CarlosLigandsSynthesis, binding properties, cell uptake and cytotoxicity of G-quadruplex ligands Synthesis, binding properties, cell uptake and cytotoxicity of G-quadruplex modified with carbohydrates
P116MuellerDianaStructureInvestigation of the Folding Kinetic of RNA G-Quadruplexes using Real-Time NMR
P117NadaiMatteoLigandsA red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
P118NgoKhac HuyBiologyUnfolding of human telomeric DNA and RNA G-quadruplexes by proteins UP1 and POT1
P119NoothanagantiAshokStructureFluorescence and X-ray Analysis of G-quadruplex Structures Using Dual-Purpose Nucleoside Probes
P120NowackJuliaLigandsCopper-induced Stabilization and Topology Switching in Unimolecular G-Quadruplexes
P121O'HaganMichaelLigandsA sweet cure for cancer? Carbohydrate-bearing ligands for G-quadruplex DNA
P122OnelBuketStructureThe 3'-End of the PDGFR-ß Core Promoter Nuclease Hypersensitive Element Forms a Mixture of Two Unique End-Insertion G-Quadruplexes That Can Be Targeted by an Ellipticine Analog
P123PaeschkeKatrinBiologyMms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability
P124PaganoAlessiaLigandsDiscovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?
P125ParkerMatthewBiologyTwo tetrad G Quadruplexes modulate expression and splicing of EXTENSIN genes in Arabidopsis thaliana
P126ParkinsonGaryMethodologyThe Use of an RNA-binding Protein as a Crystallization Scaffold for G-rich RNA Quadruplexes
P127PauloAlexandraLigandsNew V-shape modular ligands: synthesis, biophysical, biochemical and in silico studies
P128PetrMarekBiologyTumor suppressor p53 binding to MYC G-quadruplex
P129PirotaValentinaLigandsNDI-PNA conjugates targeting G4 structures within HIV-1 LTR promoter
P130PlatellaChiaraLigandsTowards High Throughput Screening method to identify G4-selective ligands
P131PodbevsekPeterStructureStructure of dimeric G-quadruplexes originating from the KRAS promoter
P132PowellBarrettUnusual (non G4) nucleic acidsPursuit of the Crystal Structure of CAGAGG Repeats in DNA
P133PozmogovaGalinaStructureA THF-based modification induces antiparallel to parallel switches in G4 DNA
P134PozmogovaGalinaStructureCpG methylation in G4 and IM structures
P135PrioleauMarie-NoelleBiologyDeterminants of replication origins in vertebrate cells
P136ProrokPaulinaBiologyFunctional analysis of G quadruplexes in metazoan DNA replication origins
P137PuntPhilipLigandsCoordination Chemistry of imidazole based ligands in G-quadruplex structures
P138RajczakEwaLigandsThe interaction between metallacrowns different type and human telomeric DNA sequence
P139RaneyKevinBiologyHelicase-catalyzed unfolding of G-quadruplex nucleic acids
P140RavichandranSubramaniyamStructureStability and Regulatory Effects of Stem-loop Containing Parallel Quadruplexes in Human Gene Promoters
P141RigoRiccardoStructureDissecting the structural features of G-rich promoter region of EGFR oncogene
P142RyazanovaOlgaLigandsBinding of cationic pheophorbide-a to Na+-containing 22-mer oligonucleotide of human telomeric repeat: a spectroscopic study.
P143RynesJanBiologyRelationship between structure and function of a polymorphic G-quadruplex formed from Pu27 element in c-MYC promoter
P144ŘímalVáclavStructureThermal changes and concentration-dependent folding of GGGN repeat
P145SaadMonaBiologyDictyostelium discoideum: A new cellular model for G-quadruplexes studies
P146SahaAbhijitLigandsTopology Probing of G-Quadruplex Structures via Ligand-Sensitized Photochemical Reactions in BrU-Substituted DNA
P147SalgadoGilmarStructureNMR Structure and Ligand Binding of a G-Quadruplex Forming Sequence Within the KRAS Proto-Oncogene Promoter Region
P148SantosTiagoLigandsSelective isolation of G-quadruplex parallel sequences with naphthalene amine affinity support
P149SaranathanNandhiniBiologyA Potential role for G-Quadruplexes in Virus Recombination
P150SasakiShogoLigandsSynthesis and evaluation of a linear hexaoxazole as G-quadruplex stabilizing ligands
P151SauerMarkusBiologyRegulation of Translation by G-quadruplex-resolving RNA Helicase RHAU
P152ScalabrinMatteoLigandsAffinity selection mass spectrometry screening of small molecules libraries for the binding to viral G-quadruplexes
P153SchwindtEikeBiologyFunctional Analysis of G-quadruplexes during Meiosis
P154Sedghi MasoudShadiLigandsSynthesis of cyclic polyoxazole compound as i-motif binder
P155Seergazhi GopalanSrivatsanMethodologyProbing G-Quadruplex Structure and Recognition Using Multifunctional Nucleoside Probes
P156SicaFilomenaStructureStructural basis for the recognition of human ?-thrombin by NU172: the only thrombin binding aptamer currently in phase II clinical trials
P157Sierra TorneroSaraLigandsG-quadruplex DNA interaction and biological activity of 1,10-phenanthroline derivatives
P158SigelRolandStructureIsolation and characterization of various equilibrium structures of the BCL2 RNA G-4plex and their interaction with metal complexes
P160SketPrimozStructureCation induced dimerization of tetrameric G-quadruplex structure
P161SorefanKarimBiologyThe function of G-quadruplexes in plants
P162SpindlerLeaStructureSelf-assembly and Diffusion of G-rich Oligonucleotides with 5'GC-ends
P163StadlbauerPetrStructureComputational Folding of RNA G-Quadruplexes
P164SteerIsobelNanotech-BiotechReal-time monitoring of interactions between naturally occurring proteins and DNA (or RNA) G-quadruplexes using Whispering Gallery Mode Resonators
P165StratmannLukasLigandsMetal-induced reversible stabilization of base modified G-quadruplexes
P166StreetStevenLigandsDivalent carbohydrate G-quadruplex ligands with a remarkable selectivity profile
P167SvehlovaKaterinaLigandsAltered biochemical specificity of G-quadruplexes with mutated tetrads
P168ŠkolákováPetraStructureRegulation of DNA i-motif formation via 5-methylation of cytosine residues: lessons learned from the epigenetic regulation of plant telomeric DNA
P169TakenakaShigeoriLigandsCyclic perylene diimides derivatives as a new type of tetraplex DNA binder
P170TerenziAlessioBiologyMultiple G-quadruplex structures in KIT promoter: a systematic study
P171TokanViktorBiologyInhibitory effect of G4s originating from plant LTR retrotransposon on expression of reporter gene
P172TsukakoshiKaoriNanotech-BiotechStructural regulation of G-quadruplex-forming aptamers by a G-quadruplex ligand
P173UrlandViktoriaUnusual (non G4) nucleic acidsTowards a High-Throughput, microfluidics based screening platform for G-quadruplex binders
P174Van NesteChristopheBiologyG-quadruplexes on the pivot point between low and high risk neuroblastoma
P175VarizhukAnnaUnusual (non G4) nucleic acidsA G-clamp analogue for i-motif stabilization
P176VergaDanielaLigandsComparison of benchmark G4 ligands: FRET melting assay vs G4-FID assay
P177ViglaskyViktorUnusual (non G4) nucleic acidsViral G-quadruplexes and their anticipated biological roles
P178VineyardWarrenBiologyConnecting G-quadruplex formation to gene expression in plants
P179WangZenghuiLigandsA photophysical study on the interaction between fluorescent platinum(II) complexes and a BCL-2 RNA G-quadruplex
P180WangYuqingLigandsDesign, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction
P181WangBaifanStructureA Reversible G-quadruplex pH Switch
P182WinnerdyFernaldo RichtiaStructureInteraction of (4n-1)-Guanine G-quadruplex with metabolite: NMR Structure of quadruplex-dinucleotide complex
P183Wirmer-BartoschekJuliaStructureNMR structure of a hybrid-2-G-quadruplex/ligand complex – structural changes in the capping region allow ligand binding
P184WrightEliseUnusual (non G4) nucleic acidsExploring the effect of epigenetic modifications on i-motif stability
P185YamaokiYudaiStructureInvention of RNA aptamer and ribozyme whose activities switch on in response to potassium ion via G-quadruplex formation
P186YonedaJulianaStructureAnisotropy of Guanosine-based hydrogels detect by SAXS
P187YouHuijuanBiologyEffects of RHAU helicase on G4 stability during the ATPase cycle
P188ZaccariaFrancescoStructureThe Role of Alkali Metal Cations in the Stabilization of Guanine Quadruplexes: Why K+ is the best.
P189ZensValerie ChristineStructureQuantitative formation of monomeric G-quadruplex DNA from higher order structures
P190ZhengSiminBiologyIntronic non-coding RNA mediates targeting of AID to DNA
P191ZhouJunStructurePosition-dependent Effects of Ribose G-quartets in G-quadruplexes